Human users
(2630 BC to present day)

Fourteen humans have been Nexus hosts, but information about most of them is unknown.
14) Noriko Null (current host)
13) Roxiana. Only known Thalassian host
12) Lexar
11) The Monk
10) unknown
9) unknown
8) unknown
7) Diomedes
6) “Subject #5”, male
5) “Subject #4”, male
4) “Subject #3”, female
3) “Subject #2”, male
2) “Subject #1”, male
1) The Scribe (first human host)

Lar users
(250 million years ago to 600,000 BC)

Known users include:

Sefer (last Lar host and creator of the Endless Winter)
Teraph (creator of the Keys of Heaven)
Malakim (first Lar host)

Demon users
(1 billion to 250 million years ago)

The Demons used the Nexus for only 30,000 years after stealing it from the Eden.
The only known user is Apocalypse.

Enslaved users
(4 billion to 1 billion years ago)

A total of over 79 million users from several unknown alien species were enslaved by the Eden and forced to use the Nexus, transferring knowledge to Eden itself.

Eden users
(4 billion years ago)

Since Eden was a collective consciousness, it is unknown how many individual bodies were hosts of the Nexus.

Pre-Eden users
(from 5 billion years ago to 4 billion years ago)

The Eden claimed that 724 hosts preceded their use of the Nexus.

Drylon users
(7 billion years ago to 5 billion years ago)

The Grimoire of Drylon Weapons estimates that the Nexus is 7 billion years old.
Thirteen Drylon are known to have used the Nexus.